Excessive tongue keratosis can be treated with retinoic acid preparations, antibiotics, or topical medications, as well as good oral hygiene. Excessive tongue keratosis is generally excessive thickening of the mucous membrane or skin keratinized layer, with retinoic acid preparations, antibiotics such as compound borax solution or furacilin solution, etc., can also be applied externally retinoic acid ointment. Try to remove the adverse stimuli as early as possible, avoid smoking, chewing betel nut, drinking alcohol, avoid eating spicy and stimulating food. Usually eat less greasy and spicy stimulating food, appropriate physical exercise, improve the body’s immunity. It is recommended to go to the stomatology department of the hospital in time for examination as well as treatment, and at the same time pay special attention to oral hygiene and cleanliness, the specific use of medication should consult a physician.