Advanced colon cancer can be treated by surgery, together with chemotherapy and radiotherapy, etc. It is necessary to choose suitable individualized treatment according to the actual condition of patients. In clinic, the lesions of advanced colon cancer are already large and usually have local or distant metastasis. When the lesion is large, patients need to reduce the size of the lesion through chemotherapy, such as using irinotecan, 5-fluorouracil and other drugs under the guidance of doctors, which can effectively control the development of the disease, alleviate the pain caused by the disease and prolong the life of patients. If patients have distant or local metastasis, they can use surgery to remove the metastatic lesions if their physical conditions permit, and at the same time cooperate with chemotherapy and local radiotherapy to avoid spreading and metastasis. Patients with advanced stage of colon cancer should be treated in time when they have physical discomfort.