Red scrotum syndrome is a chronic disease, the cause of which is still unknown, characterized by persistent erythema of the scrotum accompanied by pain and itching. 1. Clinical manifestations: the disease is most common in elderly men, with persistent erythema in the scrotum, which is well defined and of different shades, and can involve the root of the penis. Patients may feel itching or pain, and in severe cases, they may be hypersensitive to pain, which may affect their daily life, and may be accompanied by contact dermatitis and cellulitis. 2. Examination: Diagnosis can be made by physical examination, which is based on well-demarcated erythema with vasodilatation, which may be accompanied by pain, itching, burning sensation, and so on. 3. Treatment: The general treatment is topical ointment such as tacrolimus ointment, etc. Tetracyclines such as doxycycline can also be taken, the disease is not sensitive to antihistamines, antifungal drugs, glucocorticoid therapy. All of the above drugs should be applied under the guidance of a doctor. For patients suspected or diagnosed with red scrotum syndrome, they should immediately go to a regular hospital, under the guidance of a professional physician for treatment, and must not be negligent, so as not to delay the condition.