Whether creatinine returns to normal once elevated depends on the cause. If the creatinine is physiologically or acutely elevated, it may return to normal. If it is chronically elevated, it is difficult to return to normal. Physiologic elevation: creatinine rises transiently after eating a large amount of meat, or after strenuous exercise, which does not require treatment. Acute elevation: This condition is mostly seen in acute kidney injury. The patient’s creatinine rises rapidly in a short period of time. If it is pre-renal oliguria caused by heart failure, dehydration, etc. and post-renal oliguria caused by stones and prostate hyperplasia, it can be returned to normal after treating the cause of the disease. Chronic elevation: This condition is mostly seen in chronic kidney disease, renal parenchymal injury, glomerular filtration rate decreases, creatinine is difficult to return to normal, the treatment is aimed at slowing down the decline of renal function, patients need to be regularly rechecked, regular treatment. In addition, acute exacerbation of chronic kidney disease can also cause creatinine elevation, after treatment for acute factors, creatinine may drop to the level when chronic kidney disease. Once the creatinine is elevated, patients are advised to go to the hospital in time, to clarify whether there are acute and chronic factors, and to take treatment under the guidance of professional physicians.