Portal phlebitis is a septic infection of the main trunk of the portal vein and its intrahepatic branches, mostly secondary to a septic infection of the draining organ. Portal phlebitis can be caused by bacterial infection in the area draining the portal vein and its branches, and septic foci, the more common diseases, including acute suppurative appendicitis, suppurative cholangitis,, liver abscess, and so on. Portal phlebitis is characterized by high fever, chills, hepatomegaly, hepatic pain and tenderness, jaundice, abdominal muscle tension, and symptoms of the original disease. Consideration of portal phlebitis can be based on the primary disease, routine blood tests, ultrasound examination of the liver. The most common pathogens of portal phlebitis are gram-negative bacteria, such as Escherichia coli, and anaerobic infections are also seen. Treatment should actively use antibiotics, and its application principle is early, sufficient amount, combined, in order to quickly control the inflammation. Antibiotics need to be administered intravenously to increase the effective concentration of the drug in the blood as quickly as possible. Cefoperazone, ceftriaxone sodium, meropenem, imipenem and other antibiotics such as ornidazole can be used. And strengthen the systemic supportive therapy. When you consider suffering from portal phlebitis, go to the hospital in time and hospitalize for active treatment.