Lymph nodes in the neck are most commonly caused by inflammation or infection, which can be treated with anti-inflammatory therapy or anti-viral therapy, and the patient’s condition can be gradually improved. For malignant tumors with lymph node metastasis in the neck, it is a manifestation of advanced stage. If the condition allows, local lymph node excision biopsy can be performed to clarify the pathological staging and guide the next clinical treatment. Usually, systemic intravenous chemotherapy and local radiation therapy can be administered. The treatment of malignant tumor is also a comprehensive treatment, and palliative surgery can be chosen if the condition allows. Because of the prolonged lymph node enlargement and tumor depletion, a cachectic state may also occur, manifesting as anemia and hypoproteinemia, and blood transfusion may be required if necessary.