Gouty swollen ankles and the liver may be related. Gout is caused by hyperuricemia, which by itself is not very related to the liver. However, because gout patients need to take long-term medication, and the adverse effects of drugs include liver function abnormalities, serious liver function abnormalities can lead to swollen ankles, so gout patients need to regularly review liver function during the medication. In addition, if gout patients have a longer course of the disease, further damage to the kidney function, it will also cause ankle swelling, and there will be increased nocturia, proteinuria, anemia and other symptoms. Of course gout ankle swelling is the first possible factor or gouty arthritis attack, in addition to low purine diet, drink more water, may need to follow the doctor’s instructions to take non-steroidal anti-inflammatory drugs, such as etoricoxib, meloxicam and so on. Gout patients with swollen ankles should go to the hospital in time, after clarifying the specific causes of gout, under the guidance of the doctor active treatment, and regular follow-up.