Atypical antipsychotics are the first-line drugs because of their definite effectiveness and high safety in the treatment of schizophrenia, but they still inevitably cause some adverse effects, among which drug-induced liver damage (DILI) is more common. Most of the liver function abnormalities caused by atypical antipsychotics are mild and recover quickly after treatment with hepatoprotective drugs. In the early stage of treatment, liver function tests should be performed and monitored in a timely manner, the condition should be closely observed, and the dosage of drugs should be reduced or liver-protective therapy should be administered in a timely manner according to the changes to avoid adverse consequences. Patients with previous drug-induced liver damage should avoid using the triggering drugs again.