Enlargement of submandibular lymph nodes can be caused by bacterial or viral infections, lymphoma and other tumors, as well as systemic lupus erythematosus and other rheumatoid immune diseases, etc. It is possible to reduce the swelling by taking medication. 1. Infection: for bacterial infection, amoxicillin, cefaclor and other antibiotics can be taken; for viral infection, acyclovir, ribavirin can be taken; for tuberculous lymphadenitis, isoniazid, rifampicin, ethambutol and other medicines can be taken together. It can reduce the infection and thus reduce the enlargement of lymph nodes. 2. Tumor: if it is caused by Hodgkin’s lymphoma and other tumor diseases, it can be treated by applying chemotherapeutic drugs such as doxorubicin, vincristine and bone marrow transplantation; if it is caused by lymphatic metastasis of malignant tumors in other parts of the body, it needs anti-tumor treatment together with the primary tumor. 3. Rheumatic immune diseases: systemic lupus erythematosus, tuberculosis and other diseases can also lead to enlarged lymph nodes, and the symptoms can be relieved by taking prednisone, methotrexate and other drugs. If you find that the submandibular lymph nodes are enlarged, you need to go to the hospital, complete the examination, make a clear diagnosis, and then follow the doctor’s instructions to avoid self-medication.