High monocyte percentage with fever symptoms may be related to infections, blood system diseases, etc. The cause of the disease should be identified and medication should be administered under the guidance of a doctor. 1. A high percentage of monocytes in the blood routine with fever symptoms should be considered as a possibility of infection in the organism. Because monocytes and phagocytes are closely related, and phagocytes are the main component of white blood cells, which can play a role in resisting infection and killing pathogens. The presence of a bacterial or viral infection should be the first consideration for a fever with a high percentage of monocytes. Due to bacterial infection, anti-infective treatment can be given, drugs include ceftriaxone sodium, ampicillin tablets, azithromycin tablets and so on. If it is due to viral infection, oral oseltamivir phosphate capsule, paramivir injection and other drugs can be given for treatment. 2. Secondly, high percentage of monocytes with fever may be related to hematologic diseases, such as acute monocytic leukemia, once diagnosed, should be promptly given to the cytarabine, erythromycin and other drugs chemotherapy. When there is a high percentage of monocytes with fever, the patient should go to a professional hospital in time, under the guidance of the doctor for the next step in the examination and drug treatment.