Intractable hyponatremia should be supplemented with the appropriate amount of sodium, and the cause of the condition should be clarified under the guidance of a doctor for targeted treatment. Hyponatremia is serum sodium <135mmol/L. Intractable hyponatremia refers to hyponatremia that is severe and not corrected for a long time. For patients with intractable hyponatremia, the first step should be to supplement the appropriate amount of sodium, clarify the cause of the disease, and then carry out targeted treatment. The common causes of intractable hyponatremia include renal urinary dysfunction, hypopituitarism, hypothyroidism, chronic diarrhea, abnormal secretion of antidiuretic hormone, and tumors, etc. The causes of hyponatremia should be clarified under the guidance of doctors, and accurate treatments should be carried out for the causes of hyponatremia. The diet of such patients should pay attention to eat more sodium-rich foods and try not to take greasy, spicy stimulating foods to maintain the stability of blood sodium. Intractable hyponatremia may also have other causes, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or standardized treatment.