Tourette’s syndrome is a neurobehavioral disorder that has a range of symptoms that can interfere with daily life. Therefore, for some patients, medications that can reduce symptoms can improve quality of life. Of course, because medications have side effects, medication is not always the best treatment option. Clinical professionals need to carefully evaluate the pros and cons. An experienced clinician will consider the following questions: 1. Does the patient’s tics need to be treated? 2. When should treatment be started? 3. What type of treatment is chosen? What medications should be chosen? 4. What dose to choose? 5. How often should the dose be increased or decreased? 6. When to stop the medication? Choosing the right treatment plan is actually complex and often requires adjustments. The symptoms of tics are diverse, often combined with hyperactivity, obsessions and depression. Tics themselves can be “good and bad”. Current research supports that both CBIT and medication can improve tic symptoms. We will start with pharmacological treatment because there is less access to CBIT training for domestic clinicians. Some basic principles of medication Medication is not a treatment for the underlying cause of Tourette’s syndrome; the goal is primarily symptom control. At the time of treatment, the physician has to determine which symptoms are most life threatening and need to be discussed in detail when the child and parents do not recognize them. Medication for tic disorders should follow the principle of starting with low doses and adding them slowly. This makes it easier to detect drug side effects and to identify fluctuations in the therapeutic effect and the disease itself. It is not advisable to stop the medication suddenly, and if you have to, you need to consult your doctor; SSRI drugs have a rebound effect when stopped suddenly. There are many types of medications available to treat tics, but no single medication is a panacea. Commonly used medications include antipsychotics, colistin, and others, all of which have been shown to be effective. More research is needed to determine whether medications for hyperactivity worsen tic symptoms or whether they are effective for tics. Two classes of medications are widely used clinically for the treatment of tics: a2 adrenergic antagonists (e.g., colistin, guaifenesin) and antipsychotic medications. Antipsychotics are by far the most effective drugs, which mainly include typical antipsychotics (e.g., haloperidol, permethrin, etc.), and atypical antipsychotics (tebrile, sulpiride, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, etc.). Although the efficacy of typical antipsychotics is certain, due to their greater side effects, both European clinical treatment guidelines and German clinician treatment guidelines recommend atypical antipsychotics as first-line agents for the pharmacological treatment of tic disorders, while haloperidol and permethrin are mainly used as alternative drugs for severe patients.