Children with Tourette’s disease (TD), especially Tourette Syndrome (TS), have serious immune dysfunction, suppressed cellular immunity, and reduced humoral immunity, so that vaccination may not produce the expected effect of vaccination, and may even induce or aggravate the existing tic symptoms, so it is necessary to treat the vaccination of children with Tourette’s disease with caution. The results of recent studies have shown that autoimmune dysfunction may be related to the occurrence of TD, with cellular immune dysfunction predominating. When exploring the relationship between pathogenic microbial infections and the development of Tourette’s syndrome, it was found that the production of autoantibodies in TD was correlated with infections with viruses, bacteria, and mycoplasma, and so on, so that some children with TD have worsening or recurring Tourette’s symptoms after upper respiratory tract infections. Since the age of onset of TD is 2-21 years old, and the average age of onset is 5-8 years old, children with TD usually have received most of the basic immunizations at the time of their first visit to the clinic, and most of those who have not yet been immunized have received booster vaccines for the second vaccine and the basic immunizations. So what should children with Tourette’s disorder be aware of in their vaccinations? We focus on the following common vaccines. Streptococcus pneumoniae vaccine: It has been found that streptococcal infection induces obsessive-compulsive disorder (OCD) and tic disorders, which are associated with a range of autoimmune neuropsychiatric disorders in children, so it is recommended that the vaccination of Streptococcus pneumoniae should be withheld during the application of antitwitching medication for children with TD. Haemophilus influenzae and Influenza virus vaccines: Since some children with TD have increased tics after upper respiratory tract infections, nervousness, and stress, these vaccines are not recommended during anti-tics or within 3 months of remission. Measles vaccine: Measles is still a disease that affects children worldwide. In general, children with tic disorders who are first diagnosed have been immunized with the basic measles vaccine, but in special cases, a booster vaccination may be needed, and the decision of whether or not to vaccinate should be made according to the actual situation, and it is generally not recommended to be vaccinated when the symptoms of tic disorders are obvious. Diphtheria, pertussis and tetanus vaccine: Most children with tic disorders have received DPT3 and booster vaccines at the time of initial diagnosis, and most of them have high titers of specific antibodies in their bodies, so it is not recommended to be vaccinated when the tic disorder is progressing or worsening. Meningococcal vaccine: Meningitis tetravalent polysaccharide vaccine or tetravalent conjugate vaccine is an inactive vaccine, which has a good safety, but caution should be taken in the case of low immunity or immune dysfunction. In summary, TD, especially TS children, due to their severe immune dysfunction, suppressed cellular immunity and decreased humoral immunity, vaccination may not produce the expected vaccination effect, and may even induce or aggravate the existing tic symptoms, therefore, we need to be cautious about the preventive vaccination of children with tic disorders; however, there is currently less information on this area of research, and we look forward to more research results to guide the preventive vaccination of children with tic disorders. We hope that more research results will guide the vaccination of children with Tourette’s syndrome.