A systematic review and Meta-analysis conducted by Englot et al. at the University of California evaluated the rates and predictors of long-term seizure freedom in patients after refractory frontal lobe epilepsy resection and published the results in a recent issue of the Journal of Neurosurgery. Inclusion criteria for the study: at least 10 patients were seizure-free at 48 months and beyond postoperative follow-up. Twenty-one studies with a total of 1199 patients were included in the analysis. The overall postoperative seizure-free rate was found to be 45.1%; predictors of long-term seizure freedom included definable seizure foci, abnormal preoperative MRI presentation, and partial frontal resection; and in cases with definable seizure foci, total resection of the lesion significantly improved the prognosis compared with partial resection. Studies have shown that patients with focal and damage localizable frontal lobe epilepsy have higher postoperative seizure-free rates compared to patients with ill-defined lesions. Although it is possible to obtain seizure-free postoperatively in refractory frontal lobe epilepsy, invasive and non-invasive localization techniques remain to be improved.