The chances of gastric cancer in patients with thickened gastric sinuses are high. The causes of gastric sinus thickening include gastric cancer, lymphoma of the stomach, and hypertrophic gastritis, of which the incidence of gastric cancer is relatively high, the incidence of lymphoma is relatively low, and hypertrophic gastritis of the gastric sinus is not too much, so compared to gastric cancer is the most likely. If patients find thickening of the gastric sinus, they may see edema thickening from CT or gastroscopy, mostly in the leathery stomach. In gastric cancer, tumor cells under the mucosa grow along the stomach wall, so only thickening and peristaltic weakening or poor dilatation are seen. However, it is not easy to confirm the diagnosis for such patients because they repeatedly go for gastroscopy and repeatedly take tests without results. However, an experienced doctor who encounters this condition may immediately suspect a case of leathery stomach. Once the kind of situation, need to repeatedly take the examination, that is, to take the examination in large pieces and send the disease examination. Secondly, it should also be combined with CT and enhanced CT to see the extent of gastric thickening and, if necessary, with gastrointestinal imaging to assess the peristaltic fast and slow movement. Although lymphoma and hypertrophic gastritis can also present with thickening of the gastric sinuses, they are relatively rare. Overall, the possibility of gastric cancer is very high when sinus thickening is present.