Waking up with a dry and sore throat can be caused by a dry indoor environment or by a disease such as acute pharyngitis or chronic pharyngitis that causes a dry and sore throat after waking up. Different diseases, different treatment. According to the specific disease, targeted treatment, such as oral amoxicillin, cefixime, pharyngitis tablets or watermelon cream tablets and other medications. 1. Dry indoor environment: sleep indoor environment is too dry will lead to waking up with a dry throat, itchy throat, cough, etc., you can generally consider waking up in a timely manner to replenish the water to relieve, maintain indoor air circulation or the use of humidifiers, etc. to relieve the phenomenon of dry throat. 2. Acute pharyngitis: acute pharyngitis can also lead to waking up with a dry and sore throat, accompanied by fever, cough, runny nose and other symptoms, clear bacterial infection can choose to take anti-inflammatory drugs such as amoxicillin, cephalexin and so on. 3. Chronic pharyngitis: dry and sore throat with sore throat, itchy throat, dry cough, foreign body sensation and other symptoms, considering the possibility of chronic pharyngitis, you can generally consider taking throat medication such as pharyngitis tablets or watermelon cream tablets to relieve symptoms. The phenomenon of waking up with a dry and sore throat, to give the appropriate medication for the cause, if there is obvious pain and discomfort, please consult a doctor for a systematic examination to clarify the cause of the standardized medication and treatment.