Primary hypertension treatment drugs include diuretics, calcium channel blockers, β-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, vasodilators and so on. 1. Diuretics: common drugs include hydrochlorothiazide, indapamide, furosemide, spironolactone and so on. It will affect the metabolism of blood lipid and blood glucose, and have adverse reactions such as hypokalemia. Patients with renal insufficiency should follow the doctor’s instructions. 2. Calcium channel blockers: common drugs are nifedipine, amlodipine, nifedipine, verapamil extended-release agent and so on. They can cause adverse reactions such as increased heart rate and headache. Heart failure, atrioventricular block patients are prohibited. 3. β-blockers: common drugs are metoprolol, atenolol and so on. It can cause bradycardia, weakness and other adverse reactions. Acute heart failure, atrioventricular block patients are prohibited. 4. Angiotensin-converting enzyme inhibitors: common drugs are Benadryl, Captopril, Enalapril and so on. It can cause irritating dry cough or neurologic edema and other adverse reactions. Hyperkalemia, pregnant women with bilateral renal artery stenosis is prohibited. 5. Angiotensin II receptor antagonist: common drugs are valsartan, chlorosartan, timosartan and so on. It is recommended to ensure a low-salt diet while taking the drug. 6. Vasodilator drugs: hypertensive emergency can use sodium nitroprusside, nitroglycerin and other vasodilator drugs, nausea, vomiting, flushing and other adverse reactions. Aortic stenosis patients are prohibited. Primary hypertension treatment drugs are recommended to be used under the guidance of a doctor, to avoid blindly using drugs on their own.