The most obvious difference between colitis and colon cancer is the different nature of the disease, the former belongs to benign diseases, while the latter belongs to malignant tumors. In addition, there is a great difference between the two in clinical manifestations, pathogenic factors and treatment modalities. Colitis is an inflammatory lesion of the colon caused by various reasons. The lesions are mainly limited to the mucous membrane and submucous layer of the large intestine, often manifested as abdominal pain, diarrhea, mucous, pus and blood stools, and there may be systemic symptoms such as fever, or lesions in joints, skin, eyes, mouth and other places. Colon cancer is a common malignant tumor of gastrointestinal tract, which mainly manifests as abdominal pain, abdominal mass, diarrhea or constipation, and blood or pus in stool. Intestinal obstruction, anemia, emaciation, low-grade fever, ascites and other symptoms may appear in middle and late stages. In addition, some colitis may also be cancerous, which needs to be comprehensively identified according to the specific situation. If you suspect that you have colitis and colon cancer, you need to actively consult the doctor, and can confirm the diagnosis through colonoscopy and biopsy, and follow the doctor’s instructions for reasonable treatment.