Although diabetes is called “immortal cancer”, but generally as long as the blood sugar control is appropriate, no complications, then for normal life is not much harm and influence. However, complications of diabetes can seriously affect the patient’s health and may even lead to loss of life. Diabetic foot is one of the most serious and expensive chronic complications of diabetes mellitus, which refers to diabetic patients due to the combination of neuropathy and various degrees of peripheral vasculopathy, resulting in lower extremity infections, ulcer formation and (or) deep tissue destruction. The development of diabetic foot has a process, this process may be relatively slow, may also be relatively rapid, the appearance of diabetic foot usually have some pre-signs, these signs are: First, foot drop color changes: foot drop, microvascular dilatation, arterial blood pressure is low, blood flow is slow, the skin is thin and purple, such as the lower limbs will be elevated for 30-60 seconds, see the back of the foot is obviously pale. Bone and muscle changes: muscle atrophy, bowed feet or claw toes, bone decalcification and bone destruction. Third, intermittent claudication: early diabetic foot due to insufficient blood supply, to lower limb weakness, numbness, exertion, pain, can be relieved after rest. Sensory abnormalities: numbness, tingling, burning sensation in hands and feet, loss of sensation in severe cases. Fifth, rest pain, night pain: lower limb ischemia aggravated when caused by rest pain, cardiac blood transfusion decreased, night pain aggravated. Skin manifestations: malnutrition to dry skin, no sweat, become brittle and inelastic, thin, pale. When these signs appear, it is usually related to diabetic foot. Some people question whether diabetic foot pain is a sign of diabetic foot, if its foot pain occurs more frequently, and serious with resting pain, then it is indeed related to diabetic foot. This is because of the lower extremity vasculopathy of the sugar lover, the blockage of blood vessels caused by the lower extremity blood supply is insufficient, so there will be foot pain. In addition to this diabetic foot has the symptoms of numbness and coldness. If the sugar lover has these kinds of symptoms must go to the hospital in time for screening. From a single symptom, it is still impossible to diagnose whether it is diabetic foot.