Peeling and itching on the soles of the feet is most commonly seen in tinea pedis, eczema, herpes sweat, and palmoplantar keratosis. It can be treated by antifungal, glucocorticoid and anti-itching drugs. 1. Tinea pedis: tinea pedis is caused by dermatophyte infection, such as hyperkeratotic tinea pedis, mainly manifested as local dryness, thickening, roughness, and flaking. Salicylic acid and compound benzoic acid ointment can be given to soften the skin. Then use amorolfine rub, miconazole ointment, if necessary, with oral itraconazole capsule treatment. 2. Eczema: foot eczema is a common clinical itchy skin disease that may lead to localized peeling. Topical glucocorticoid ointment such as mometasone furoate ointment, hydrocortisone butyrate cream can be given, and oral loratadine, levocetirizine, ketotifen and other medications can be given. 3. Sweat herpes: the cause of sweat herpes has not been fully clarified, easy to occur in the hands and feet, resulting in localized clusters of blisters, blisters will also peel after drying. Sweat herpes has a tendency to heal on its own, but is prone to recurrence. Depending on the extent of the disease, doctors will give patients loratadine, zinc oxide ointment, tacrolimus ointment, tretinoin urea ointment, to accelerate the relief of symptoms. 4. Palmoplantar keratosis: Congenital palmoplantar keratosis, usually caused by heredity. Salicylic acid and retinoic acid cream may be given. Secondary palmoplantar keratosis, which may be secondary to eczema, tinea pedis, lichen planus, etc., needs to be treated for the primary disease. There may be other reasons for the itchy peeling of the soles of the feet, it is recommended to go to the hospital in a timely manner, to identify the causes, symptomatic treatment, the above drugs need to be used in accordance with the doctor’s instructions.