The sensation of blockage in the ear is a symptom that may be caused by cerumen embolism, secretory otitis media, Meniere’s disease, etc. It needs to be treated in conjunction with the specific disease, and there is no fastest way to eliminate the sensation of blockage in the ear. 1. Cerumen impaction: Patients with cerumen impaction can have their cerumen removed by softening with 5% sodium bicarbonate solution, rinsing with warm saline, or suction with a suction device. 2. Secretory otitis media: it can be treated with antibiotics, such as erythromycin and cefuroxime under the guidance of doctors, and glucocorticosteroids, such as dexamethasone and prednisone, etc.; glucocorticosteroids nasal sprays, such as budesonide nasal spray, etc.; and nasal decongestants, such as 1% ephedrine solution and hydroxymethizoline hydrochloride spray. Conservative treatment is ineffective or serious condition of patients can be surgical treatment, such as tympanic membrane puncture fluid extraction, or tympanotomy tube treatment. 3. Meniere’s disease: patients can use vestibular nerve inhibitors, such as diazepam, phenelzine, etc.; anticholinergic drugs, such as scopolamine, etc.; vasodilators, such as flunarizine, betahistine, etc.; diuretics, such as hydrochlorothiazide, etc. under the guidance of the doctor for treatment, to alleviate the labyrinthine effusion, improve the symptoms of ear blockage. It is recommended that patients strictly follow the doctor’s instructions for medication, actively cooperate with the doctor’s treatment, pay attention to observe their own condition in life, and once aggravated, seek medical treatment in a timely manner.