Hiccups may be caused by physiological factors or pathological factors such as chronic gastritis, reflux esophagitis, gastric ulcer and other diseases, and are mostly treated with medication. Physiological factors: eating too quickly, easy to ingest too much air, causing involuntary contraction of the diaphragm, resulting in non-stop hiccups. Pathological factors: 1. Chronic gastritis: chronic gastritis patients with gastric mucosa stimulation caused by gastrospasm, stimulating gastrointestinal peristalsis upward reversal after persistent or intermittent hiccups. You can take digestive enzyme preparations such as compound digestive enzyme tablets to promote gastrointestinal digestion; you can also take gastric mucosal protective agents such as aluminum thiosulfate to enhance the gastric mucosal defense ability. 2. Reflux esophagitis: the contents of the stomach or duodenum reflux into the esophagus, causing lesions of the esophageal mucosa, irritation of the esophagus resulting in hiccups. You can take acid-suppressing drugs such as omeprazole to inhibit the secretion of gastric acid; you can also take gastrointestinal stimulants such as domperidone to increase the pressure of the lower esophageal sphincter, improve esophageal peristalsis and promote gastric emptying. 3. Gastric ulcer: patients with gastric ulcer have poor digestive function, which will stimulate the diaphragm to cause spasms, resulting in hiccups. The patient can take medicines to inhibit gastric acid secretion such as omeprazole as prescribed by the doctor; if there is Helicobacter pylori infection, the patient can take the quadruple regimen containing bismuth for the eradication of Helicobacter pylori treatment. 4. Gastrointestinal neurosis: in patients with gastrointestinal neurosis, gastrointestinal peristalsis is weakened, causing diaphragmatic spasm and hiccups. Old hiccups may also be seen in other diseases, it is recommended that timely treatment under the guidance of a doctor.