The use of PPIs (proton pump inhibitors) may elevate gastrin 17. PPIs refer to proton pump inhibitors, mainly represented by the drug omeprazole, which is mainly used to inhibit gastric acid secretion. Gastrin 17 is a gastrointestinal hormone synthesized and secreted by gastric sinus G cells. Its main function is to stimulate gastric acid secretion and promote gastrointestinal motility. Chronic gastritis, gastric sinus cancer and other diseases may cause abnormal gastrin 17. The main mechanism of PPI is to inhibit the mural cell H+-K+-ATPase to inhibit the secretion of gastric acid, so that the secretion of gastric acid is reduced. It is mainly used to treat gastric ulcer, reflux esophagitis and other diseases.The PH value of gastric juice may be elevated after PPI inhibits gastric acid secretion.Gastric sinus G cells sensing the elevated PH may reflexively increase the secretion of gastrin 17, which leads to its elevation. If the serum gastrin 17 test level is abnormal, it is recommended to go to the hospital in time to identify the cause and then carry out targeted treatment.