High glutamyl transpeptidase is mostly caused by liver and biliary tract diseases, therefore, for patients with high glutamyl transpeptidase, they should avoid drinking alcohol for a long period of time, avoid eating high-calorie and high-fat foods, and eat foods rich in vitamins, such as fruits and vegetables, and should also pay attention to rest, and do physical exercise appropriately, and need to be given symptomatic treatments according to the specific causes of glutamyl transpeptidase increase. The treatment should be based on the cause of the elevated GATP. If it is caused by fatty liver and alcoholic liver, in addition to the above mentioned cases, appropriate liver-protecting drugs should be given orally, such as MENENG and SIMETHYL, and so on. For high glutamyl transpeptidase caused by stones or tumors, in this case, only surgical treatment can achieve good results. For stones, the problem of stones can be solved by laparoscopic choledochotomy and stone extraction with T-tube drainage, percutaneous hepatic puncture choledochoscopic stone extraction and endoscopic ERCP stone extraction. For patients with tumors, laparoscopic radical cholangiocarcinoma surgery, laparoscopic hepatic cancer resection, and laparoscopic pancreaticoduodenectomy are also needed to achieve better results. In more severe cases, where patients cannot tolerate surgery, interventional placement of stents is also needed to address the problem of jaundice. For acute and chronic hepatitis caused by high glutamyl transpeptidase, the first step should be to give active antiviral treatment, such as oral entecavir or adefovir, and pay attention to the regular review of hepatitis B five and viral DNA quantification, to adjust the dosage of drugs.