Rectal ulcer mainly refers to the chronic non-specific ulcerative disease that occurs in the rectum, which can be treated by taking drugs and surgery. 1. Drug treatment: mainly choose salicylic acid preparations, antibiotics and cortisol drugs. (1) Salicylic acid preparations: commonly used drugs include mesalazine tablets, mesalazine enema solution, etc. They are mainly used to reduce patients’ intestinal inflammation to promote ulcer healing. (2) Antibiotics: commonly used drugs include third-generation cephalosporin antibiotics, such as cefdinir, ceftriaxone, etc.; or quinolone antibiotics, such as levofloxacin, norfloxacin, etc., which are mainly used to reduce inflammatory reactions in the rectum and prevent complications. (3) Cortisol drugs: such as prednisolone, dexamethasone, etc., which can be used to reduce inflammation as well as promote ulcer repair. (2) Surgery: Rectal resection is usually used to remove the diseased intestinal tubes to achieve the purpose of healing. All of the above drugs are contraindicated for those who are allergic to them and should be taken in accordance with the doctor’s instructions. If the patient is diagnosed with rectal ulcer, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor to carry out targeted treatment, in order to reduce the adverse effects of the disease.