Non-steroidal, caffeine and antihistamine ingredients contained in cold medicines may cause gastrointestinal damage, poor mental health, addiction and other symptoms with long-term use. 1. Non-steroidal drugs: long-term use can form damage to the mucous membrane of the digestive tract, mildly affecting the digestive function, and in severe cases may cause peptic ulcer and other diseases. It can also cause drug fever, leukopenia, allergy caused by skin rashes, coagulation disorders caused by bleeding, renal insufficiency and so on. 2. Caffeine: It is the ingredient contained in most of the cold medicines, but if used for a long time, it can form an addictive manifestation. Once discontinued, drowsiness and depression may occur. 3. Antihistamine: is commonly used in anti-allergy drugs contain ingredients, long-term use can inhibit nerve function, resulting in fatigue, poor mental health, inability to concentrate and other symptoms. Drugs need to be used according to the condition of the doctor’s instructions reasonable and standardized, do not use their own long-term use of cold and flu medicines.