Prevention of spermatozoa, an impossible dream. Patients with schizophrenia and other psychiatric disorders have defective brain inhibition, a pathophysiological impairment of the brain associated with sensory gating deficits and attentional dysfunction. The development of brain inhibitory function is perinatal and is influenced by genetic and in utero factors. Amniotic choline activates fetal alpha-7 nicotinic acetylcholine receptors, thereby promoting the development of brain inhibition. By increasing this stimulatory process to promote normal brain development, the infant may be protected from future disease. a study published in the American Journal of Psychiatry in March 2013 showed that perinatal choline supplementation promotes the development of brain inhibition in infants; shattering the long-held belief that preventing mental illness is an unattainable dream. The study was the first randomized human clinical trial performed under the U.S. Food and Drug Administration’s (FDA) New Drug Exemption Study to improve the risk of disease associated with pathophysiological impairment.