There are no so-called early signs of leukemia in children, but the early stage of the disease may show anemia, frequent infections, bruising and bleeding, bone or joint pain, abdominal discomfort, and swollen lymph nodes. 1. Anemia: When the bone marrow hematopoietic stem cells are inhibited, symptoms of anemia may appear, such as fatigue, dizziness, pale skin, feeling of coldness, and lack of energy. 2. Frequent infections: Children with leukemia have high white blood cell counts, but most of these cells do not work properly. White blood cells help protect the body and fight infection, and repeated and persistent infections may indicate that a child does not have enough healthy white blood cells. 3. Bruising and bleeding: As a result of thrombocytopenia, children are prone to bruising, nosebleeds or bleeding gums and need to be alerted to leukemia. 4. Bone or joint pain: When leukemia develops, abnormal cells will gather in the joints or near the surface of the bones, resulting in bone or joint pain, which is most common in the long bones of the limbs and the finger bones, without localized redness or swelling. 5. Abdominal discomfort: abdominal pain may also be an early symptom of leukemia. Leukemia cells can accumulate in the kidneys, liver and spleen, causing enlargement of these organs. Abdominal pain may lead to loss of appetite and weight loss. 6. Swollen lymph nodes: The child’s lymph nodes in the armpits, groin, chest or neck may become swollen. If your child develops any of these symptoms, it is advisable to visit the hospital promptly for a detailed examination to rule out leukemia.