Rectal administration is a common form of medication administration in children. Generally speaking, rectal drug delivery is very safe and does not cause any significant harm. What is rectal drug delivery: rectal drug delivery refers to the method of drug delivery through the anus into the intestinal canal, through the rapid absorption of the rectal mucosa into the blood circulation, to exert drug effects to treat systemic or local diseases. There are three main methods of rectal drug delivery: retention enema method, rectal drip method, and suppository insertion method. Pediatric rectal mucosa blood circulation is strong, absorption capacity is very strong, drugs can enter the circulation through three ways. (1) Through the superior rectal vein through the portal vein into the liver metabolism and then circulate the whole body. (2) Through the middle rectal vein, the inferior vein and the anal canal vein, bypassing the liver, directly into the large circulation. (3) After absorption through the rectal lymphatic system, it enters the circulation through the celiac pond and the thoracic duct. Advantages of rectal administration: rectal administration of pediatric drugs is simple and easy, but also safe and effective, can reduce the pain of injections and medications, for infants and young children who do not easily accept injections and oral administration of drugs, easy to administer drugs and improve the compliance of drug delivery; rectal administration of drugs is absorbed faster than oral administration, to avoid drug destruction in the gastrointestinal tract. Disadvantages of rectal administration: small rectal absorption area, irregular absorption of drug administration; only for drugs that are easily absorbed in the rectum, not easy enough to use and restricted. The drug is more effective when the rectum is empty (just after defecation); children with diarrhea must make up the amount of liquid and then give the drug rectally. In addition, prolonged rectal administration in children may damage the rectal mucosa and may cause infection. If rectal administration is needed, it should be done under the guidance of a doctor.