Nasopharyngeal cancer T4N1 generally means that the condition of nasopharyngeal cancer has reached stage IV, which belongs to the middle-late stage. Nasopharyngeal cancer is a kind of malignant tumor occurring in nasopharynx, which is a common malignant tumor in clinic, and its symptoms mainly include nasal congestion, stuffy ears and blood in snot. There is a clear staging of nasopharyngeal cancer, which is usually judged according to the size of the tumor and the degree of tumor spreading and metastasis, i.e. TNM staging. T refers to the tumor, which can be divided into T1.T2.T3.T4 according to the size of the extent of tumor invasion; N refers to the lymph nodes, which can be divided into N0, N1.N2.N3; M refers to the distant metastasis. From this point of view, T4 refers to intracranial invasion of the tumor, involving cranial nerves, hypopharynx, orbit, parotid gland or extensive soft tissues and exceeding the extensor pterygoid muscle; N1 refers to unilateral cervical lymph node metastasis or unilateral and bilateral retropharyngeal lymph node metastasis. Regardless of whether there is distant metastasis T4N1 belongs to stage IV nasopharyngeal cancer. One should go to regular hospital in time to choose suitable and correct treatment mode under the guidance of professional doctors for targeted treatment.