A low HbA2 result of 2.4 is not necessarily thalassemia.
HbA2 is a kind of hemoglobin, its normal value is 2.5~3.5, accounting for 2%~3% of the total hemoglobin content. 2.4 low HbA2 can be seen in ferrocytic anemia, iron deficiency anemia, etc. 1.
1. Mildly elevated or increased HbA2 values in adults are commonly found in patients with β-thalassemia, and the determination of HbA2 levels has a certain reference value for the diagnosis of thalassemia. Therefore, if the HbA2 value is low, β-thalassemia can be basically excluded.
In β thalassemia heterozygotes, HbA2 is reduced; in heterozygotes, HbA2 is completely absent. β β thalassemia heterozygotes, only HbF is present, and neither HbA nor A2 is present.
2. Low HbA2 can also be seen in iron granulocytic anemia and iron deficiency anemia, so differential diagnosis of thalassemia needs to be made by genetic testing, etc. Therefore, it cannot be determined by one of the above tests.
Therefore, thalassemia cannot be determined by one of the above tests. It is recommended to go to the hospital in time, and give targeted treatment or therapy after completing the examination to clarify the cause of the disease under the guidance of the doctor.