Melanosis of the elbow is generally caused by friction melanosis due to the long-term extrusion and friction of this area, resulting in pigmentation. There is no such thing as the most effective way to remove it. Clinical treatments include general treatment and medication. 1. General treatment: patients should first reduce the adverse stimuli, try to avoid the elbow area by excessive pressure or friction, and at the same time should pay attention to this part of the cleanliness and hygiene. 2. Medication: patients can use urea ointment and vitamin E cream under the guidance of the doctor. You can also apply Vitamin A cream at night. At the same time can also be applied to promote melanin metabolism of drugs, such as tranexamic acid, arbutin and so on. For patients with melanin deposits in the elbow area, if they are self-conscious of the aesthetic impact, it is recommended to go to a regular hospital for examination and treatment under the guidance of a professional doctor.