Juvenile systemic lupus erythematosus (JSLE) is an autoimmune mediated diffuse connective tissue disease with immune inflammation as the main manifestation. Over the years, we have accumulated nearly 200 cases of JSLE, and after analyzing these cases, we found that: 1. Age and gender at the onset of JSLE: ① Age older than 6 years accounted for 98%, ② 19% for boys and 81% for girls. The most frequent clinical conditions at the onset of JSLE were: ① renal damage 59.6%, most of them with large amounts of proteinuria and edema, ② fever 57.4%, ③ skin damage 53.2%, ④ hematologic abnormalities 46.8%, … joint pain 36.2%, ? renal combined with hematologic lesions 25, 5%. 3. The abnormalities of laboratory tests in JSLE were: ①100 % positive for antinuclear antibody, ②91,4% decreased serum C3, ③59,6% abnormal urine routine (hematuria/leukocyturia/proteinuria), ④51,1% positive for anti-ds-DNA antibody, … 46,8% abnormal blood routine (leukopenia/hemoglobinopenia/thrombocytopenia) … Anti-Sm antibodies were positive 31,9%. 4. From the above clinical and laboratory tests, we can draw the following conclusions: ① Children, especially those over 6 years old, with unexplained fever, rash, arthralgias, swelling or abnormal urine tests, bleeding spots or abnormal blood tests should be seen by a specialist, and the possibility of JSLE can be clarified by combining physical examination, laboratory tests and other relevant tests. (2) Renal damage at the beginning of the disease accounts for 59.6% of children with JSLE, and some of these patients have only renal involvement, lacking other manifestations such as fever and arthralgias, which may omit the differential diagnosis of JSLE. Lupus nephritis is the main factor affecting the prognosis of JSLE, and renal failure is one of the main causes of death in JSLE. Lupus nephritis is the most important factor affecting the prognosis of JSLE, and renal failure is one of the main causes of death in JSLE, and treatment of lupus nephritis is the top priority in the treatment of JSLE.