The high prevalence of SLE is in adult women. Approximately 15-20% of patients with SLE may develop the disease in childhood. Compared to adults, pediatric patients have a more severe clinical presentation and organ damage appears more quickly. If not treated aggressively. The prognosis of SLE in children is worse than that of adults, with an increased number of episodes. It is second only to juvenile rheumatoid arthritis. It is the 2nd most common rheumatic disease in children. SLE is an autoimmune disease that affects multiple systems and organs and has a variety of clinical manifestations. The first symptoms vary, 1. Except for a few cases with acute onset. The early manifestations are mostly non-characteristic. The early manifestations of autoimmune diseases may include fever, general malaise, malaise, weight loss, joint pain, etc. The early manifestations may include signs of a certain system or an organ, such as rash, oral ulcer, hair loss, lymph node enlargement, anemia, purpura, impaired consciousness, disorientation, mental regression, convulsions, interstitial or substantial pneumonia, pericarditis, etc. The early manifestations may include abnormalities in one or several laboratory indicators, such as Proteinuria or hematuria, abnormal blood count, unexplained increased erythrocyte sedimentation rate, abnormal liver function, abnormal electrocardiogram, etc. The clinical diagnosis of typical cases is easy, but atypical cases need to exclude infectious diseases, hematologic diseases, malignant diseases, other autoimmune diseases, skin diseases, allergic diseases, etc. before diagnosis can be made. Most patients with positive serum autoantibodies and high titers are helpful for diagnosis, but comprehensive analysis is still needed for diagnosis. Treatment measures The treatment of SLE in children includes general treatment and drug treatment. 1. General treatment: (1) Patients and their families should correctly understand the disease, eliminate fear, cooperate with treatment, follow medical advice, recognize the importance of long-term follow-up, avoid excessive UV exposure and excessive fatigue, and apply anti-UV products. (2) Remove all kinds of factors affecting the prognosis of the disease, bed rest, strengthen nutrition and avoid sun exposure during the acute period. 2. Drug treatment: NSAIDs, hydroxychloroquine, adrenal glucocorticoids, immunosuppressants, etc. Although the drugs for treating SLE have various adverse reactions, it is because the clinical application of these drugs can effectively control and relieve the disease and improve the quality of life of patients, and through regular and effective detection of adverse drug reactions, the adverse drug reactions can be further reduced and the prognosis improved.