HPV59 positivity must be followed by a cervical TCT, or cervical liquid-based cytology, after detection. If the cervical liquid-based cytology reveals atypical squamous cells, or low or high grade squamous epithelial cells suspicious, a colposcopic cervical biopsy must be done to clarify the presence of cervical lesions. If HPV59 is positive, but TCT does not reveal atypical squamous cells and no malignant cells are seen, and it only shows inflammation of the cervix, no special treatment is needed, only HPV recheck every two years and regular annual TCT. for HPV59 high-risk virus positive, the main treatment methods currently adopted are interferon antiviral therapy, or povidone-based vaginal pessary Anti-viral therapy. HPV is a human papillomavirus, which is associated with cervical cancer and has more than 160 subtypes, 14 of which are high-risk positive. For patients with positive high-risk types, it is mainly necessary to have regular TCT examinations to detect whether there are cervical lesions through TCT examinations in a timely manner.