Cracked tongue has horizontal cracks and vertical cracks, which may be caused by 21-Trisomy Syndrome, Riboflavin Deficiency, Mero Syndrome, etc. It can be treated by general, medication and surgery. 1. 21-Trisomy Syndrome: also known as Down’s Syndrome, there are usually symptoms such as dull expression, thick tongue, mental retardation, etc. Horizontal fissures on the tongue may occur, and may even cause complications such as infections and epilepsy. It is usually treated by other means such as speech therapy, behavioral therapy, etc. In case of complications, the complications can be treated by taking penicillin V potassium tablets, carbamazepine tablets, and other types of medicines such as anti-infective and anti-epileptic, etc., and so on. 2. Riboflavin deficiency: there are usually symptoms such as weakness and lateral fissured tongue, which can be treated by taking vitamin B2 tablets, amoxicillin capsules and other drugs. 3. Mero syndrome: it is a rare disease with symptoms such as facial swelling, vertical fissured tongue and facial paralysis. It can be treated by taking dexamethasone tablets, azathioprine tablets and other drugs, or by surgical excision of the right suture to treat the deeper grooves of the fissured tongue, but also through acupuncture and other physical therapy to improve local circulation and eliminate edema. The symptoms of cracked tongue, it is recommended that under the guidance of a doctor to clarify the cause of treatment and medication, to avoid self-medication, causing discomfort.