Gray nails may be caused by infections such as Trichophyton rubrum and Trichophyton suis. The main causative organism of gray nail is the red trichophyton, trichophyton fungus, and some molds in dermatophytes, most of which are directly infected by tinea pedis, when dermatophytes invade the nail plate, they can release all kinds of enzymes to decompose the nail plate, which leads to the destruction of the nail plate, and due to the lack of cellular immunity of the nail of the toes and the easy susceptibility of the fungus, it makes the nail plate suitable for the long term survival of the fungus, which results in the formation of gray nails. In addition, when the patient has nail trauma, tinea pedis, wear impermeable shoes, local blood or lymph circulation disorders, impaired immune status will cause the formation of gray nails, the patient’s main clinical manifestations of turbidity, thickening, separation, atrophy, shedding, warping, and inguinal inflammation and so on. It is recommended that patients go to the regular hospital in time, under the diagnosis of the doctor, according to the patient’s specific condition, to take targeted treatment, life should pay attention to personal hygiene habits, to maintain a regular life habits, appropriate exercise.