Most patients with hand, foot and mouth disease have a good prognosis, with a morbidity and mortality rate of less than 1%. There is no need to panic after the emergence of hand, foot and mouth disease, the first thing should be disinfection and isolation, to avoid cross-infection. To pay attention to rest diet, to light, easy to digest, vitamin-rich food, oral ulcers can be liquid food, prohibit stimulating food. Herpes of the oropharynx can be applied with gold or cod liver oil, or watermelon cream or ice borax can be blown on the affected area of the mouth. Herpes of hands and feet can be treated with ice borax and gold powder applied to the affected area, and ruptured herpes can be treated with local rubbing of nail violet or antibiotic ointment. Patients with fever and fever need to be treated; those with diarrhea and abdominal pain should pay attention to rehydration and correction of electrolyte disorders. For pathogenic treatment, there are no highly effective antiviral drugs available, so ribavirin antiviral therapy can be given as appropriate, and patients with severe disease should be actively hospitalized.