Acne is generally referred to as acne vulgaris, and factors such as genetics, androgen-induced sebum production in large quantities, keratinization of follicular sebaceous gland ducts, propagation of Propionibacterium acnes, and immune-inflammatory response may be associated with it. Acne that turns into hard bumps on the cheeks can be treated by general treatment, medication, and photodynamic therapy. 1. General treatment: For general treatment, choose water or a suitable cleansing product to remove excess oil from the skin surface, and use a mild moisturizing lotion externally. Avoid squeezing and scratching the skin lesions with hands. Appropriately limit the intake of high glycemic index foods and milk that may trigger or aggravate acne, keep bowel movement smooth, and avoid staying up all night. 2. Medication: Topical benzoyl peroxide gel can be used to kill Propionibacterium acnes, dissolve pimples and astringent effect; topical fusidic acid and other antibiotics can also be used to treat. 3. Photodynamic therapy: Photodynamic therapy is the topical 5-amino ketoglutaric acid (ALA) enriched in the follicular sebaceous gland units, plus illumination of red light, applicable to severe acne. Patients whose acne on the cheeks turns into hard bumps need to consult a doctor in time and choose a treatment plan according to their situation after the doctor’s interview.