Some studies have shown that offspring conceived by IVF are slightly more likely to develop certain physiological structural defects and perinatal disorders, such as congenital malformations and cardiac malformations. From a scientific point of view, there is no significant difference between the offspring of IVF and those conceived naturally in terms of fertility, intelligence, psychology, etc.; however, some studies have shown that the offspring of IVF conception are more prone to physiological defects, such as congenital malformations, cardiac malformations, hyperbilirubinemia, etc., as compared to those of natural conception. However, if the couple has chromosomal abnormalities, three generations of IVF are usually required, which can minimize the problem of abnormal genetic material in the embryo. The offspring of IVF in this case are not only free of defects, but are healthier than those conceived naturally. Therefore, couples who have the idea of IVF-assisted reproduction should not blindly believe in the rumors, but should choose the appropriate IVF program after full evaluation by the doctor.