Vomiting three times for the fourth time after taking simethicone may be a side effect of the drug, or the patient may have other gastrointestinal or neurological disorders that cause vomiting, which is an abnormal condition, and prompt medical attention is recommended. The most commonly reported adverse reactions in clinical trials of simethicone were gastrointestinal disorders, including nausea (very common), diarrhea (very common), and vomiting (common), and should be used as directed by a physician. These include the possibility of irritation of the gastrointestinal mucosa, causing mild or moderate gastrointestinal reactions such as nausea, diarrhea, and vomiting, which are usually of short duration. In addition, vomiting three times for the fourth time after taking simethicone may be due to reflex vomiting due to gastrointestinal, hepatobiliary-pancreatic, and peritoneal disorders, as well as central vomiting due to infections that are neurologic, systemic, or toxic. Multiple vomiting is not necessarily related to simethicone medication, the above diseases may cause patients to vomit multiple times, you need to consult a doctor in a timely manner, under the guidance of the doctor to clarify the cause of the disease, do not adjust the simethicone medication without authorization. After excluding gastrointestinal diseases, neurological diseases and other factors that do not cause vomiting, if the symptoms are not relieved, it is necessary to adjust the drug under the guidance of a doctor or take other treatment measures.