The lumbar vertebrae S1 through S5 affect the bladder, bowel, and sexual function. There are 31 pairs of spinal nerves in total, and there is a corresponding correspondence between spinal nerves and vertebrae, which penetrate the vertebral or sacral canal from the intervertebral foramina above or below the vertebrae of the same sequence. Lumbar vertebrae S1 to S5 correspond to the spinal nerve segments from the first to the fifth sacral nerves, which are mainly responsible for the activities of the mesentery and the organs in the pelvis. The nerves in the lumbar vertebrae S1 to S5 segments belong to the sacral plexus, which has somatic nerves in the feet, ankles, calves, knees, thighs, etc., and visceral nerves in the bladder, intestines, and reproductive organs. If the lumbar S1 to S5 nerves are compressed or damaged, corresponding symptoms will appear in their distribution areas, such as sciatic nerve compression will appear in the numbness of the lower limbs of both lower limbs, pain, menstrual irregularities, hemorrhoids and other symptoms. If the lumbar S1 to S5 nerves are damaged, corresponding treatment measures should be taken in time, and different methods are often adopted according to the different degrees of damage, mainly surgical treatments (e.g., various types of nerve decompression) and conservative treatments (e.g., oral methylcobalamin tablets, injections of senkyu glucose), and also non-steroidal anti-inflammatory drugs can be used to alleviate the symptoms and promote the recovery of the nerves. Nerve cells are weak in repairing, therefore, nerve injury often has more sequelae, and should be emphasized and diagnosed and treated as early as possible to avoid aggravation of the injury, which may lead to incalculable consequences. The use of the above drugs should be in accordance with medical advice.