Hepatic encephalopathy is less likely to cause pain symptoms, the disease mainly leads to cognition, consciousness and other mental abnormalities, but does not exclude some special circumstances, the specific diagnosis and treatment need to follow the doctor’s advice. Hepatic encephalopathy is a disease caused by liver dysfunction leading to central nervous system dysfunction, with personality change, cognitive dysfunction, behavioral abnormality, orientation abnormality, and consciousness disorder as the main clinical manifestations. Pain is not a typical symptom of this disease and is relatively rare clinically. However, in some cases, such as the presence of cirrhosis, pain in the hepatic area may occur due to the pulling of the liver cell membrane and the stimulation of the intrahepatic bile ducts, or in more serious cases, pain may occur due to confusion or hallucinations. Therefore, the possibility of pain symptoms in hepatic encephalopathy cannot be completely excluded. In conclusion, hepatic encephalopathy does not necessarily present pain manifestations, as a critical condition, the specific diagnosis and treatment of this disease should be carried out strictly under the guidance of the doctor, do not blindly judge and dispose of it on your own, so as not to cause adverse consequences.