Right vocal fold squamous epithelial atypical hyperplasia with ulcer is precancerous lesion, which is more serious. Atypical hyperplasia of squamous epithelium with ulceration of the right vocal fold suggests that the tissue cells of the right vocal fold have undergone abnormal changes and have a tendency to transform into malignant tumors, which is more serious. Some patients may have no self-awareness of the symptoms, and most of them are discovered only when they undergo a puncture biopsy. If treatment is actively given, it is likely to get better without progression or enlargement. However, if atypical hyperplasia of the squamous epithelium of the right vocal fold involves the entire epithelial layer, the probability of cancerous transformation increases and is generally difficult to reverse. Therefore, squamous epithelial hyperplasia of the right vocal fold with ulcers is recommended to be consulted as early as possible, and standardized treatment under the guidance of physicians, so as to avoid delaying the condition.