Herpes zoster is a respiratory-transmitted viral infection, which is a neurophilic varicella-herpes virus that is latent in the sensory ganglia after infection into the bloodstream, and when the body’s resistance decreases, it replicates in large numbers in the sensory ganglia neurons and spreads through the peripheral nerves to the skin, causing lesions (blisters). Herpes zoster is self-healing and the lesions (blisters) will heal on their own within 2-3 weeks without treatment. Some people think that since it heals on its own, there is no need for treatment. In fact, it is the lesion that heals itself, but because the injury is not only localized to the skin, but also to the sensory nerves, the injured nerves are prone to ectopic discharges and cross-communication due to demyelination and scar formation, leading to central sensitization of the nerves, thus causing intractable neuralgia. The incidence of postherpetic neuralgia can be more than 50% in patients over 50 years of age with herpes zoster. Not only does postherpetic neuralgia (PHN) not heal on its own, but it is also very difficult to treat. Therefore, it is recommended that regular and adequate courses of antiviral, nerve-nourishing, and analgesic treatment be administered promptly after the onset of the disease to reduce the incidence of postherpetic neuralgia. Postherpetic neuralgia is diagnosed when the pain remains for more than a month after the scab has healed. Postherpetic neuralgia is a persistent neuropathic pain that often manifests as spontaneous pain and abnormal sensory pain. The spontaneous pain is characterized by paroxysmal or persistent pins and needles, knife-like, burning, electric shock-like pain or flashing or throbbing pain; the abnormal sensory pain is characterized by nociceptive hypersensitivity or hypersensitivity: the skin of the affected area feels painful when it is slightly rubbed by clothing, and the pain is often heavy at night, and patients often cannot sleep at night and are in pain. In some cases, the pain can last for months, years, or even more than a decade, and oral treatment with common analgesics is ineffective. Postherpetic neuralgia needs to be treated as early as possible. The earlier the intervention, the more definite the effect, and the longer the delay, the more difficult it is to control. Single treatments are usually not well controlled and require comprehensive treatment. At present, the treatment methods used are: comprehensive drug regulation, physiotherapy, neurointervention, and neuromodulation technology, etc., which can obtain good treatment results. In our pain center, 25 cases of intractable postherpetic neuralgia were treated with CT-guided radiofrequency thermal coagulation of the dorsal root of the spinal nerve combined with chemical destruction of adriamycin, with precise results and patient satisfaction.