Crooked mouth, also known as crooked corners of the mouth, is categorized into central causes and peripheral facial paralysis. Central causes are mainly due to acute cerebrovascular diseases, such as cerebral infarction, transient ischemic attack, cerebral hemorrhage, resulting in damage to the motor nerves of the patient, which will lead to the symptoms of crooked mouth. This may be accompanied by tongue deviation, speech clumsiness, or limb paralysis and weakness, and requires timely examination and treatment in a hospital. Crooked corners of the mouth may also be caused by facial neuritis, such as cold, wind, or infected with a virus that causes the facial nerve to be attacked, edema, will lead to paralysis of the facial muscles of the patient, manifested as crooked corners of the mouth. At this time the patient in the frontal line is also symmetrically disappeared or reduced, the treatment should be given to the nutrition of the facial nerve, in the acute stage may have to be given hormones to reduce the swelling of the facial nerve, and in the later stage to help the patient paralyzed muscle recovery through the Chinese medicine acupuncture, to improve the patient’s symptoms of crooked mouth.