The relationship between selenium and liver disease is mainly because selenium is an important substance to fight against liver disease, and many liver diseases are related to selenium deficiency in the body. Selenium has a very important role for the liver, such as improving the body’s immunity, conducive to the improvement of liver disease; improve the liver’s antioxidant capacity, prevention and control of hepatocellular necrosis, prevention of liver fibrosis; Blocking the genetic mutation of liver disease virus, easy to recover from liver disease patients and protect the liver; selenium and some liver-protecting drugs used together can strengthen the efficacy of the drug and reduce drug side effects and adverse reactions. Selenium is a trace element, is essential to the human body, in the body of the liver is one of the most selenium-containing organs, and many patients with liver disease by checking the body more selenium deficiency, and the more serious the condition, the more selenium deficiency. If the symptoms of hepatitis B aggravate, it is not easy to get better with the lack of selenium in the body has a great relationship, so patients with liver disease pay attention to selenium supplementation to improve the regression of liver disease has a very good effect.