Type II grade 3 papillary renal cell carcinoma can be treated with surgical resection, drug therapy, radiotherapy and chemotherapy. 1. Surgery: papillary renal cell carcinoma type II grade 3 has a high recurrence rate and is often accompanied by distant metastasis, so it needs active intervention and radical surgery to avoid distant metastasis. 2. Drug therapy: if distant metastasis has occurred, oral antitumor drugs, such as sunitinib, sorafenib, pazopanib, can be taken, and radiotherapy can be used if necessary. The drugs should be applied under the guidance of doctors. 3. General treatment: papillary renal cell carcinoma type II grade 3 needs to strengthen nutritional support after operation, in addition to standardized medication, regular rechecking is also needed to avoid recurrence, and attention should be paid to rest in daily life to keep a good state of mind. Patients with papillary renal cell carcinoma type II grade 3 should go to regular hospitals in time and take standardized treatment under doctors’ guidance to avoid deterioration of the condition.