Rheumatoid arthritis patients adhere to the medication, the joints will still appear discomfort may be the drug did not work or need to adjust the treatment program, there may be aggravation of the disease, it is recommended that the patient in time for rheumatology and immunology consultation. Rheumatoid arthritis patients adhere to the medication and discomfort symptoms may be considered to be the drug did not work, because the general anti-rheumatic drugs work more slowly, this situation can continue to take drugs. If the course of medication is sufficient, there is still joint discomfort, need to consider adjusting the drug program, it is recommended to timely rheumatology and immunology consultation, under the guidance of a professional doctor to adjust the treatment program. If patients still have discomfort after regular and sufficient medication and adjustment of the treatment program, it is necessary to consider that the disease is progressing and aggravating, and surgery and other surgical treatments can be considered while actively adjusting the program. Rheumatoid arthritis patients adhere to the medication or have uncomfortable symptoms, should be timely rheumatology and immunology to consult a doctor, follow the doctor’s instructions to use medication, avoid blind use of drugs, so as not to cause adverse reactions.