Pyrazinamide, one of the tuberculosis drugs, can cause joint pain. In addition to joint pain, pyrazinamide can also cause hyperuricemia, liver damage, loss of appetite, nausea and other symptoms, so if the joint pain caused by pyrazinamide is relatively mild, it is not necessary to stop the drug. If pyrazinamide causes particularly severe arthralgia, accompanied by severe hyperuricemia or liver damage, pyrazinamide can be discontinued and replaced with other drugs. Commonly used anti-tuberculosis drugs include isoniazid, rifampicin, ethambutol, streptomycin, etc., and pyrazinamide can be replaced with other bactericides of choice.